Abstract
Hypoxia may improve the biological activity of nitroreductase (NTR). The development of effective methods for monitoring the activity of NTR plays an important role in the early diagnosis of tumors. Toward this goal, we have developed a new two-photon fluorescence NTR probe CoNO2-HY with fast response, high sensitivity and selectivity, and a large turn-on fluorescence signal. The probe CoNO2-HY could monitor endogenous NTR in living HeLa cells. Importantly, the probe CoNO2-HY is successfully applied to detect the endogenous NTR in the tumor tissue of mice with the penetration depth up to 90μm.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
