A Fast and Reliable Screening Setup for Homogeneous Catalysis with Gaseous Reactants at Extreme Temperatures and Pressures

Abstract

Modern catalysis research strongly focusses on optimizing multiple reaction parameters en route to find optimal conditions. However, a very limited number of fundamental parameter combinations, such as inert conditions, gaseous reactants, variable temperature, and elevated pressure, can be screened in a convenient and straightforward manner. We report a ready-to-use reaction setup that is designed for screening reactions with gaseous reactants under inert conditions in standard NMR tubes (0.5 mL) using temperatures between −40 and +100 °C and extreme pressures. Proof-of-concept reaction examples are discussed, and the coupling to modern analytic techniques including in situ IR spectroscopy is possible.