Abstract
The functions of lipids as signaling compounds and their interorganelle transport are topics that have recently moved to the center stage of cell biological and biomedical research. In this context the concept of membrane contact sites (MCS), sites of close apposition of organelle membranes, is an emerging major theme. An increasing number of studies have revealed crucial roles of such contacts as sites with prominent functions in interorganelle lipid transport and metabolism as well as signaling nodes, and molecular machineries operating at MCSs are being identified (reviewed by ). One of the protein families reported to localize at membrane contacts are the Oxysterol-binding protein/OSBP-related proteins (ORPs), sterol/phospholipid binding proteins implicated in a variety of cellular functions: lipid metabolism and transport, vesicle transport and signaling cascades .
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
