Abstract
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseases, etc.
Highlights
Worldwide, stroke is the second leading cause of death and the most common cause of adult disability[1,2]
Less than 100 have been tested in human clinical stroke trials[9], and virtually all trials have been negative. These poor odds identify the translation from preclinical studies to clinical trials as a bottleneck in identifying drug targets relevant to human disease [Figure 1A]. These trial failures led to a period of deep introspection in the field, with many questioning the validity of preclinical animal models for discovering novel drug targets for translation to human clinical trials[10,11,12]
We hypothesized that using ΔNIHSS as a quantitative trait with genome-wide-association studies (GWAS) would reveal genetic variants, genes, or pathways related to early ischemic brain injury mechanisms, and provide insight into potential drug targets
Summary
Stroke is the second leading cause of death and the most common cause of adult disability[1,2]. Despite five decades of translational research on ischemic brain injury mechanisms, there are no widely accepted neuroprotective drugs for the treatment of AIS. These poor odds identify the translation from preclinical studies to clinical trials as a bottleneck in identifying drug targets relevant to human disease [Figure 1A].
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