A factor toxic to chick embryos in blood of tumor bearing animals

Abstract

Blood from animals bearing solid metastasizing tumors, leukemias, and lymphomas produced a high rate of mortality of chick embryos ( 40–100 per cent) within 7 days when inoculated onto the chorioallantoic membrane. In contrast, similarly inoculated blood from normal animals, those bearing tumors which do not metastasize, those with inflammatory lesions and granulomas and those with alterations in normal physiology was relatively innocuous and caused only a low percentage ( 0–30 per cent) of death of chick embryos.