A Facile Synthetic Route to Biologically Relevant Substituted 1,4‐Naphthoquinonyl‐2‐oxoindolinylpyrimidines Under Metal‐Free Organocatalytic Conditions

Abstract

AbstractA simple, straightforward, and highly efficient three‐component one‐pot synthesis of a series of substituted 5‐(3‐(3‐hydroxy‐1,4‐naphthoquinon‐2‐yl)‐2‐oxoindolin‐3‐yl)pyrimidine‐2,4,6(1H,3H,5H)‐triones as biologically relevant molecular hybrids has been accomplished based on a tandem reaction of substituted istains, 2‐hydroxy‐1,4‐napthoquinone and barbituric acid in the presence of sulfamic acid as a low‐cost and eco‐friendly organocatalyst in aqueous ethanol under reflux. High atom‐economy, good yields, metal‐free synthesis, eco‐friendliness, and operational simplicity are some of the important features of this protocol.