Abstract
A well-dispersed SiO2@Layered hydroxide cupric benzoate (SiO2@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO2@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and FTIR spectra provide consistent evidence to the formation of SiO2@Cu-LBMS nano-microspheres. The release behavior and drug loading capability of SiO2@Cu-LBMS microspheres were also investigated by using ibuprofen, aspirin and salicylic acid as model drugs. The results indicated that the drug loading capability of SiO2@Cu-LBMS nano-microspheres was much larger than layered hydroxide cupric benzoate, and the releasing time was significantly prolonged than layered hydroxide cupric benzoate and their physical mixture.
Highlights
Drug delivery systems are designed to either alter pharmacokinetics and biodistribution of their associated drugs, or to function as drug reservoirs
During the past several years, many nanomaterials have been used in drug delivery systems, such as mesoporous silica (MS) [2,3,4], mesoporous magnesium carbonate (MMC) [5], highly porous amorphous calcium carbonates (HPACC) [6], polymeric nanoparticles [7], liposomes [8], carbon nanodots (CDs) [9] and brucite-like materials [10,11,12,13,14,15,16,17]
We have reported the structure of layered basic metal salts (LBMS) [32], in which
Summary
Drug delivery systems are designed to either alter pharmacokinetics and biodistribution of their associated drugs, or to function as drug reservoirs. This will enhance several crucial properties of “free” drugs, such as improving their solubility, in vivo stability and specificity, and reducing or eliminating tissue damage [1]. MS, MMC and HPACC are inorganic nanomaterials, and the mechanism of drug loading mainly depends on pore adsorption. MS presents better performance such as high pore volume and large surface area, but the drug loading capacity was relatively lower than other materials and the release of drugs depends mainly on pore size.
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