Abstract

Synthesis of 3-vinyl- and 3-alkyl-Δ 3-cephems was performed in a regioselective manner by palladium acetate catalyzed reaction of 3-sulfonato- or 3-bromo-Δ 3-cephems with dialkylzinc or vinyltributyltin. A new access to 3-alkyl-Δ 3-cephems is opened, starting from the allenyl compound 10.

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