Abstract
Bio-Organic Science Division, Korea Research Institute of Chem ical Technology, P.O. Box 107, Yusong, Daejeon 305-600, KoreaReceived March 10, 2004Key Words : Chloropyridine, nAChR, Conformational rigidity, π-Cation interaction, DihydropyrrolopyridineThe chloropyridine moiety confers high potency to severaltypes of analgesics and insecticides acting at nicotinicacetylcholine receptors (nAChRs). This includes (−)-epibatidine 1, isolated from the skin of Ecuadorian poisonfrog Epipedobates tricolor .
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