Abstract
A simple and facile synthesis of racemic 15-deoxy-Δ12,14-prostaglandin J2 methyl ester from readily available Corey lactone diol in total eleven steps was suggested. The standard methods provided a pathway to a block with an integrated w w w-chain and further to PGJ2 methyl ester. The latter was smoothly converted to the target prostaglandin in the TsOH–CH2Cl2 medium when allylic alcohol moiety was transformed to exocyclic diene substituent conjugated with endocyclic enone system.
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