Abstract
One-pot three-component synthesis of novel macrocyclic imidazolidines has been accomplished in good yields via a facile [3+2] cycloaddition reaction of azomethine ylide, derived from paraformaldehyde and sarcosine, with various macrocyclic imines as dipolarophiles. The effect of solvent on the [3+2]-dipolar cycloaddition reaction is also studied.
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