Abstract
Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO2 nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models. The highly porous hybrid scaffolds are shown to be super-compressible, which is typically forbidden in materials of biological origin. We demonstrate that the hybrid scaffolds concurrently display both adsorption and absorption behavior in the removal of oil and dye molecules, respectively from contaminated water. This study paves the way for the development of novel multifunctional and shape recoverable hybrid materials specifically from renewable resources.
Highlights
Collagen is the basic structural protein found in the skin and connective tissue and it plays a vital role in maintaining the structural integrity of the extracellular matrix (ECM) architecture[8,9]
We synthesized hybrid scaffolds using type-I collagen extracted from leather industry wastes, TiO2 nanoparticles and cross-linked with oxidized sago starch derived from agro-industry
We synthesized a hybrid collagen scaffold incorporated with TiO2 nanoparticles from collagenous wastes using the freeze-drying method
Summary
Various reports are available on the preparation of different natural and synthetic polymer-based sponges/scaffolds for tissue engineering[2,3], wastewater treatment[4], heavy metal removal[5,6], and oil spill cleaning[7]. Many collagen-based scaffolds such as Mucograft, Alloderm, and Integra are commercially available for biomedical applications[15,16] Most of these products are composed of native collagen alone and the stability of them at the wound site is uncertain. Other than the biomedical applications, the hybrid collagen sponges can be used effectively for environmental remediation applications such as oil spill cleaning and dye removal. We synthesized hybrid scaffolds using type-I collagen extracted from leather industry wastes, TiO2 nanoparticles and cross-linked with oxidized sago starch derived from agro-industry. The usefulness of hybrid sponges in the removal of spent oil and dye was studied along with its reusability assessed through super compressibility
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