A facile and efficient carbodiimide-mediated synthesis of dihydroquinazolines via a tandem nucleophilic addition-intramolecular hetero conjugate addition annulation strategy

Abstract

A novel and efficient method is described for the synthesis of dihydroquinazoline derivatives which involves initial addition of a nucleophile (alcohol, amine and thiol) to the carbodiimide cumulenic system followed by intramolecular hetero conjugate addition annulation.