Abstract
AbstractAsymmetric 1,3‐dipolar cycloaddition of methyl α‐fluoroacrylate with azomethine ylides for the construction of optically active fluorinated pyrrolidines bearing one unique fluorinated quaternary and two tertiary stereogenic centers has been achieved with Cu(CH3CN)4BF4/TF‐BiphamPhos complexes for the first time. This catalytic system performs well over a broad scope of substrates, providing the synthetically useful adducts in good yields and excellent diastereoselectivities and good to high enantioselectivities.
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