Abstract
A one-pot synthesis of 2-naphthol derivatives is accomplished using a tandem Friedel-Crafts reaction sequence. The developed methodology allows for a concomitant construction of up to three C-C bonds between readily available alkynes and phenylacetyl chloride derivatives by an intermolecular Friedel-Crafts acylation of alkynes followed by an intramolecular Friedel-Crafts alkylation of β-chlorovinyl ketone intermediates.
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