Abstract
A face serum composed of a combination of biologically active compounds was evaluated for safety and efficacy in vitro, in a repeat insult patch test and in a human clinical efficacy trial. The serum inhibited tyrosinase activity modestly, decreased collagenase activity and exhibited notable free radical scavenging activity in vitro. It is gentle to the skin, as the serum did not irritate the skin or produce symptoms of allergic contact dermatitis in the 55 healthy adults that participated in the repeat insult patch test. In the efficacy trial, daily application of the face serum for 30 days significantly increased skin hydration, with all 35 volunteers experiencing improvement. Substantial improvements in skin elasticity, roughness (fine lines and wrinkles), and brightness also occurred during the trial. Dermatological examination also revealed a trend for reduced comedone count with use of the serum. Self-assessment responses revealed that all volunteers experienced improvements in multiple skin quality parameters and that participant perceptions are consistent with the results of the instrumental analyses. These findings indicated that the measured improvements in skin quality are not only statistically significant but are also clinically relevant as they were great enough for users of the face serum to feel and recognize.
Highlights
The skin is a major protective organ of the human body
It is gentle to the skin, as the serum did not irritate the skin or produce symptoms of allergic contact dermatitis in the 55 healthy adults that participated in the repeat insult patch test
These findings indicated that the measured improvements in skin quality are statistically significant but are clinically relevant as they were great enough for users of the face serum to feel and recognize
Summary
The skin is a major protective organ of the human body. It provides first-line protection against numerous potential threats in our environment. The disappearance of this water-binding molecule results in the characteristic age-associated decrease in skin hydration status [19]. The serum was formulated to provide a comprehensive antiaging topical treatment which would mitigate the adverse effects of environmental and intrinsic factors on the extracellular matrix as well as reduce some of the visible effects of aging. Such a formulation could aid users in their efforts to maintain a youthful appearance and promote overall well-being
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