A Eu (III) metal–organic framework as sensitive fluorescent sensor for p-nitroaniline, treatment activity on the stigma and mental disorders in syphilis patients by regulating the dopamine content in the brain

Abstract

In the present experiment, a new metal–organic framework (MOF) containing Eu(III) of {[Eu(CA)(OA)0.5(H2O)2]·H2O}n (1, in which H2OA = oxalic acid and H2CA = chelidonic acid) has been generated by using the solvothermal reaction approach. The as-prepared Eu-MOF was investigated for the high sensitive detection performance for the p-nitroaniline, a harmful chemical in food and water. As a kind of luminescent sensor, the Eu-MOF reflects an obvious fluorescent quenching toward the p-nitroaniline, while other similar nitroaromatic compounds only show weak quenching effects. To relieve the stigma and mental disorders in syphilis patients, the dopamine content in cerebrospinal fluid was detected by the enzyme-linked immunosorbent detection kit after the compound treatment. In addition to this, the real-time reverse transcription polymerase chain reaction was also implemented for the detection of the dopamine receptor relative expression levels in the striatum.