Abstract
The concept of three dimensional (3D) dosimetry by optical-computed-tomography (optical-CT) of radiation induced optical contrast was first introduced in 1996 (Gore J C, Ranade M, Maryanski M J and Schulz R J 1996 Phys. Med. Biol. 41 2695-2704 and Maryanski M J, Zastavker Y Z and Gore J C 1996 Phys. Med. Biol. 41 2705-2717) and developed later by other groups. These works describe a first generation optical-CT system based on measurement of the transmission of single scanning laser beam that scanned the dosimeter in a rastering manner. Second generation systems can be categorized as macroscopic scanners developed for 3D dosimetry, and microscopic scanners developed for embryo imaging. Here we introduce a new system that bridges this divide. It is designed to be a dual purpose, micro-optical-CT system, with capability to perform both 3D micro-dosimetry on dosimeters up to 5 cm diameter, and to image structure and function of optically cleared tissue samples in transmission mode (optical-CT) and emission mode (optical-ECT).
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