Abstract
1. 1. Q O 2 measured in a Warburg respirometer was found to be stimulated by the addition of external Na +. The relationship between extra Q O 2 and the concentration of Na + displays saturation kinetics, the maximal effect occurring at 40–60 mM. 2. 2. 2,4-Dinitrophenol stimulated Q O 2 and inhibited the short-circuit current (s.c.c.). The maximally effective concentration of dinitrophenol was the same for both, 5·10 −5–10·10 −5M. 3. 3. The addition of Na + (40 mM) in the presence of dinitrophenol (1·10 −4M) produced a further marked stimulation of Q O 2 . The effects of varying the concentration of dinitrophenol on this Na +-independent Q O 2 paralleled the effects on s.c.c. and Na +-independent Q O 2 . 4. 4. The results are interpreted as showing a direct stimulation of the respiratory chain by Na + per se.
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