A Drug Interaction Between Zafirlukast and Theophylline

Abstract

1. Katial RK, 2. Stelzle RC, 3. Bonner MW, 4. Marino M, 5. Cantilena LR, 6. Smith LJ (1998) Arch Intern Med. 158:1713–1715. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] #### Purpose of the Study The apparent low adverse effect profile of the new drug zafirlukast has made it an attractive choice in the treatment of asthma. This study describes the first case of a potentially serious drug-drug interaction between zafirlukast and theophylline. ##### Study Population, Methods, and Results A 15-year-old white girl with asthma had been taking theophylline (Slo-bid, Rhone-Poulenc Rorer Pharmaceuticals Inc, Collegeville, PA) (300 mg twice daily), with drug levels of approximately 61 micromol/L (11.0 μg/mL) for several years. Recently, her serum theophylline levels had increased to the toxic range (133.2 μL/L [24 μg/mL]) … [1]: {openurl}?query=rft.jtitle%253DArchives%2Bof%2BInternal%2BMedicine%26rft.stitle%253DArch%2BIntern%2BMed%26rft.issn%253D0003-9926%26rft.aulast%253DKatial%26rft.auinit1%253DR.%2BK.%26rft.volume%253D158%26rft.issue%253D15%26rft.spage%253D1713%26rft.epage%253D1715%26rft.atitle%253DA%2BDrug%2BInteraction%2BBetween%2BZafirlukast%2Band%2BTheophylline%26rft_id%253Dinfo%253Adoi%252F10.1001%252Farchinte.158.15.1713%26rft_id%253Dinfo%253Apmid%252F9701106%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/archinte.158.15.1713&link_type=DOI [3]: /lookup/external-ref?access_num=9701106&link_type=MED&atom=%2Fpediatrics%2F104%2FSupplement_2%2F393.2.atom [4]: /lookup/external-ref?access_num=000075234500017&link_type=ISI