Abstract
This study investigated whether mixture extract of <em>Pterocarpus indicus, Momordica charantia, Phaseolus vulgaris</em> and <em>Andrographis paniculata</em> could lower plasma glucose in Type 2 Diabetes Mellitus (T2DM) patients. 43 T2DM patients, consist of 10 male and 33 female patients participated in this possitive-controlled, double-blind, and crossover clinical study with administration of either mixture extract (22 mg/kg BW) or glibenclamide 5 mg daily in breakfast time. Treatment of extract or glibenclamide was administered for a month, then medication was changed after a week of washout period and finally combination therapy was administered after wash out period as well. The efficacy of mixture extracts was measured by using Fasting Plasma Glucose (FPG) and two-hour Postprandial Plasma Glucose (PPG). Forty-one subjects completed the study. Data was analyzed using SPSS 19 with Student's t test, and p&lt;0.05 was considered significant. FPG level significantly decreased 16.07 mg/dl after extract, 43.34 mg/dl after glibenclamide and 50.16 mg/dl after combination treatment. Two-hour PPG level decreased 25.88 mg/dl after extract, 66.61 after glibenclamide and 58.93 after combination treatment. We concluded that extract administration could lower FPG and PPG although not as good as glibenclamide treatment did and combination treatment was the best to lower FPG.
Highlights
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This study investigated whether mixture extract of Pterocarpus indicus, Momordica charantia, Phaseolus vulgaris and Andrographis paniculata could lower plasma glucose in Type 2 Diabetes Mellitus (T2DM) patients
50% T2DM patients were allocated to group A that would receive extract treatment first and the rest of T2DM patients were allocated to group B that would receive glibenclamide administration
Summary
The study was designed as a prospective, randomized, doubled-blind, comparative positive controlled, crossover, clinical trial. Treatment group was administered with a dose of mixture extract Pterocarpus indicus, Momordica charantia, Phaseolus vulgaris and Andrographis paniculata. Positive control group was administered a daily dose of glibenclamide (5 mg). Both groups received combination treatment of mixture extract and glibenclamide
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