A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

Yan Hu,Sheng Hu,Jie Hu,Siyi Dong,Li Kang,Xinzhou Yang,Shangwen Zhang

doi:10.1038/s41598-021-88503-1

Yan Hu, Sheng Hu + Show 5 more

Open Access

https://doi.org/10.1038/s41598-021-88503-1

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Journal: Scientific Reports	Publication Date: Apr 28, 2021
Citations: 60	License type: open-access

Affiliation: South Central University for Nationalities

Abstract

A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods.

Highlights

A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared
The inner layer of the double-layer hydrogels was made of sodium alginate (SA) and carboxymethyl cellulose (CMC), which was dripped into the CaCl2 solution
The formation mechanism was physical crosslinking between Ca2+ and COO− and the inner diameter of the hydrogel can be controlled by modifying the composition ratio of SA to CMC43

Summary

Introduction

A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. A two-layer hydrogel system with different internal/external structures and properties was formed through the selection and optimization of materials and crosslinking methods, which laid the possibilities for construction a novel oral sustained-release drug delivery system.

Results

Conclusion