Abstract
Double, double, no toil and trouble: Enantiomerically pure tetrahydrofurans are obtained with high position- and stereoselectivity through a ruthenium(VII)-catalyzed oxidative cyclization of 5,6-dihydroxy alkenes (see scheme TPAP=tetrapropylammonium perruthenate). A dual activation modifies the reactivity and increases the carbophilicity of the transition metal so that an otherwise unusual dioxygenation with perruthenate occurs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have