Abstract
In a double-blind, crossover, sequential trial, oral thyrotrophin-releasing hormone (T.R.H.) (40 mg.) given daily for a week was no more effective than placebo in treating twenty-nine depressed outpatients. There was no clinical or biochemical evidence that patients continuing on oral T.R.H. (40 mg. daily) maintenance therapy after completion of the trial became hyperthyroid, even when T.R.H. was administered for 12 weeks.
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