Abstract
Objectives: There is growing recognition of the important role of metronomic chemotherapy for cancer treatment. Based on their unique antiangiogenic effects, we tested the efficacy of combination chemotherapy with albumin-bound paclitaxel (ABP), which stimulates thrombospondin-1, and topotecan, which inhibits hypoxia-inducible factor 1-alpha, at metronomic dosing in ovarian carcinoma.
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