Abstract
Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) ϵ, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr–DNA pol α enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J. Řı́man and A. Šulová, Acta Virol. 41 (1997) 181–214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol α, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed.
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