Abstract
This review describes recent developments in enantioselective imine reduction, including related substrates in which a CN bond is the target for reduction, and in situ methods.
Highlights
Active amines are essential functional groups in many biological molecules
This review aims to cover recent developments in the field of imine reduction by using Asymmetric hydrogenation (AH), asymmetric transfer hydrogenation (ATH) and organocatalytic reductions
This review primarily focuses on recent reports on catalysts based on iridium, ruthenium and rhodium, for AH and ATH for imines and subsequently organocatalytic reduction using chiral phosphoric
Summary
This review aims to cover recent developments in the field of imine reduction by using AH, ATH and organocatalytic reductions. Jonathan Barrios-Rivera completed an MSci at Queen Mary University London in 2017 and is currently a PhD student at Warwick working under the supervision of Professor Wills. His project is concerned with the development of novel asymmetric catalysts based on Ru(II) complexes. Dr Yingjain Xu is a former PhD student of Professor Wills, having completed a PhD at Warwick University in 2005 He worked with Professor John Brown at Oxford University before joining Phosphonics. In this review we have tried to capture the remarkable range of exciting new synthetic chemistry methodology which has been developed during the course of these internationally-ranging studies
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