A Direct Metal‐Free Synthetic Approach for the Efficient Production of Privileged Benzimidazoles in Water Medium under Aerobic Condition

Abstract

AbstractA metal‐free methodology for the synthesis of 1,2‐disubstituted and 2‐substituted benzimidazoles with high to excellent yields has been developed. The course of synthesis involves easy work‐up, straightforward purification, inexpensive reaction setup, and wide substrate scope under extremely mild and operationally simple conditions which makes the synthetic strategy more lucrative, practical and reliable. The serious challenge to carry out these reactions in a pure aqueous medium has been achieved at 75 °C in presence of air bubbles. The applicability of this operationally simple and metal‐free synthetic approach for the gram‐scale synthesis of benzimidazole derivatives with good yield (∼74%) further strengthens its potentiality for the synthesis at an industrial scale.