Abstract
Translation of polyA+ RNA from rat hypothalami in a reticulocyte lysate system yields a 19 000 dalton (19k) preproform which reacts with antibodies against bovine neurophysin II (Np II) and arginine vasopressin (AVP). Co-translational addition of canine microsomal membranes gives rise to a glycosylated 22 000 (22k) proform which co-migrates with an AVP Np II common precursor extracted from rat hypothalamus. These rat precursors correspond to those obtained by translation of bovine mRNA except that the latter have molecular weights of 21 000 (21k) and 23 000 (23k), respectively (Schmale and Richter, 1981). Also as in the bovine system a second precursor with a molecular weight of 16 000 (16k) is synthesized from rat mRNA which reacts with anti Np II but not with anti AVP.
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