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Abstract
Naringin is a dihydroflavonoid, which is rich in several plant species used for herbal medicine. It has a wide range of biological activities, including antineoplastic, anti-inflammatory, antiphotoaging, and antioxidative activities. So it would be interesting to know if naringin has an effect on aging and aging-related diseases. We examined the effect of naringin on the aging of Caenorhabditis elegans (C. elegans). Our results showed that naringin could extend the lifespan of C. elegans. Moreover, naringin could also increase the thermal and oxidative stress tolerance, reduce the accumulation of lipofuscin, and delay the progress of aging-related diseases in C. elegans models of AD and PD. Naringin could not significantly extend the lifespan of long-lived mutants from genes in insulin/IGF-1 signaling (IIS) and nutrient-sensing pathways, such as daf-2, akt-2, akt-1, eat-2, sir-2.1, and rsks-1. Naringin treatment prolonged the lifespan of long-lived glp-1 mutants, which have decreased reproductive stem cells. Naringin could not extend the lifespan of a null mutant of the fox-head transcription factor DAF-16. Moreover, naringin could increase the mRNA expression of genes regulated by daf-16 and itself. In conclusion, we show that a natural product naringin could extend the lifespan of C. elegans and delay the progression of aging-related diseases in C. elegans models via DAF-16.
Highlights
Aging is accompanied by constant changes in morphology and gradual decline in function
To investigate if naringin could extend the lifespan of C. elegans, the wild-type C. elegans N2 was treated with naringin from stage L4 larva or early adult till their death
Our results showed that naringin increased the lifespan of C. elegans in a dosedependent manner (Figure 1(b), Table S1)
Summary
Aging is accompanied by constant changes in morphology and gradual decline in function. Aging is a major risk factor for human diseases including cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases [1,2,3]. Many epidemiological studies have shown that natural bioactive products could reduce the risk of agingrelated diseases [5,6,7]. A number of natural bioactive products, including phosvitin [8], royal jelly-collagen peptide [9], Alaskan berry extracts [10], walnut protein hydrolysate [11], and tea extracts [12], exhibit longevity extension abilities. Naringin exhibits multiple biological activities and pharmacological effects, including antitumor [14], antihypercholesterolemic [15], desensitization [16], antiallergy, antiphotoaging [17], cytoprotective [18], anti-inflammatory, heart-protective [7, 13, 19, 20], and neuroprotective activities [21,22,23]. Given the various biological activities reported, we are wondering if naringin
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