Abstract
Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ( D̄) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average D̄ ( p=0.02) and lower D̄ histogram peak height ( p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.
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