Abstract
A theoretical description of 1H- 1H dipolar nuclear spin relaxation in a multispin system has been worked out by forming a diffusion equation for a one-dimensional chain of equidistant spins. The spin-diffusion equation is formed from first principles by assuming nearest neighbor interactions for a molecule undergoing isotropic random reorientation. This equation describes diffusion only in the long correlation limit (for ( ωτ c > 1.118) and is solved for driven NOE experiments, for spins in a chain of infinite length (0 < × < ∞), or for spins in a chain of finite length (0 < × < L). The solutions are obtained using the method of the Laplace transform for specified initial and boundary conditions. The observed selectivity of the NOE transfer in driven NOE experiments on a biomolecule which has a correlation factor ωτ c ∼ 3 is indeed in conformity with the predictions obtained from the spin-diffusion equation.
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