Abstract
With polytrauma, more than 30% of victims are diagnosed with severe blood loss, grade III MARINO of the leading components is transfusion therapy, which aims to restore the erythron system and improve the functional state of the oxygen transport system. The addition to intensive care of substances that affect lipid peroxidation and energy status of cells can reduce the number of heterogeneous transfusions and thus reduce the number of complications in the postoperative period. Such substances may be a solution of ceruloplasmin with a leading antioxidant effect and a solution of D-fructose-1,6-diphosphate sodium salt of the hydrate with an energetic effect. Criteria for exposure to these substances should be indicators such as blood levels of hemoglobin, phosphorus, malonic dialdehyde and lactate / pyruvate ratio.
Highlights
Analysis of injuries in recent years has shown a significant (3 times) increase in the number of victims with combined trauma complicated by shock with blood loss [1, 2]
This study is based on the analysis of the results of a comprehensive clinical-instrumental and laboratory dynamic study of hemodynamic, biochemical in 96 patients with polytrauma who were treated at the polytrauma department and intensive care unit for patients with combined trauma in Kharkiv City Clinical Emergency Hospital in the period 2017 - 2020, which evaluated the effectiveness of the proposed treatments in the process of cohort prospective randomized simple open-label clinical trial
Since there are no absolute indications for heterologous blood transfusion, and the severity of the patient's bleeding does not depend on the level of hemoglobin and hematocrit, it is important to differentiate the approach to infusion and transfusion therapy in victims with polytrauma with heavy blood loss
Summary
Analysis of injuries in recent years has shown a significant (3 times) increase in the number of victims with combined trauma complicated by shock with blood loss [1, 2]. Mortality in this group of victims reaches 68-90% [3, 4]. One of the leading conditions in providing emergency care to victims with combined chest and abdominal trauma with polytrauma is intensive care, the focus and significance of which depends on the timely diagnosis of the severity of the victim, volume, degree and rate of blood loss [5]. With adequate infusion-transfusion therapy, primarily with the possibility of reinfusion, the clinical condition of patients improves from the first day of stay in the intensive care unit [9, 10]
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