Abstract
We thank Drs Nohe and Dieterich for their comments on our recent article in this journal, in which we reported that physiological concentrations of bovine serum albumin (BSA) and recombinant human serum albumin (HSA) selectively inhibit TNFα-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in human aortic endothelial cells [1]. In contrast, neither E-selectin nor intercellular adhesion molecule-1 (ICAM-1) expression were inhibited by BSA [1]. We also observed that BSA inhibits TNFα-induced VCAM-1 expression in human umbilical vein endothelial cells (HUVEC) [2]. This result is consistent with the inhibitory effect of HSA on TNFα-mediated VCAM-1 expression in HUVEC reported by Nohe et al. [3]. However, these authors also found that contaminants in two different preparations of HSA can upregulate expression of ICAM-1 and E-selectin in resting and TNFα-stimulated HUVEC, respectively [3]. Nohe …
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