Abstract
SummaryA strain difference in the response to hypoxia of the CAF1 and CF1 mice is described. The CF1 strain developed significant erythropoietin production in response to hypoxia, and after 3 weeks marked polycythemia. In the CAF1 mouse both erythropoietin production and polycythemia were minimal. Both strains produced comparable amounts of erythropoietin in response to post-hemorrhagic or hemolytic anemia. The implications of these differences are discussed.
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