A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects.

Juscelino Tovar,Rickard Ekesbo,Ulla Johansson,Maria Johansson,Ann-Margreth Aberg,Anne Nilsson,Inger Björck

doi:10.1186/1743-7075-9-29

Juscelino Tovar, Rickard Ekesbo + Show 5 more

Open Access

https://doi.org/10.1186/1743-7075-9-29

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Journal: Nutrition & Metabolism	Publication Date: Jan 1, 2012
Citations: 74	License type: cc-by

Affiliation: Lund University, Healthcare in Sweden

Abstract

BackgroundDifferent foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD).MethodsFourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia ≤ 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods, oily fish as source of long-chain omega-3 fatty acids, viscous dietary fibers, soybean and whole barley kernel products, almonds, stanols and a probiotic strain (Lactobacillus plantarum Heal19/DSM15313).ResultsAlthough the aim was to improve metabolic markers without promoting body weight loss, minor weight reductions were observed with both diets (0.9-1.8 ± 0.2%; P < 0.05). CD did not modify the metabolic variables measured. AD promoted significant changes in total serum cholesterol (-26 ± 1% vs baseline; P < 0.0001), LDL-cholesterol (-34 ± 1%; P < 0.0001), triglycerides (-19 ± 3%; P = 0.0056), LDL/HDL (-27 ± 2%; P < 0.0001), apoB/apoA1 (-10 ± 2%; P < 0.0001), HbA1c (-2 ± 0.4%; P = 0.0013), hs-CRP (-29 ± 9%; P = 0.0497) and systolic blood pressure (-8 ± 1%¸ P = 0.0123). The differences remained significant after adjustment for weight change. After AD, the Framingham cardiovascular risk estimate was 30 ± 4% (P < 0.0001) lower and the Reynolds cardiovascular risk score, which considers CRP values, decreased by 35 ± 3% (P < 0.0001).ConclusionThe improved biomarker levels recorded in healthy individuals following the multifunctional regime suggest preventive potential of this dietary approach against CMD.

Highlights

Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations
An increasing number of studies show that different functional foods and ingredients [9,10] may exert positive effects on particular parameters related to the metabolic syndrome (MetS), a cluster of pathophysiologic conditions increasing cardiometabolic risk [11,12,13]
The present investigation explores the cardiometabolic diseases (CMD) preventive potential of a diet based on a combination of functional concepts, chosen on the basis of their beneficial effects on single metabolic risk markers

Summary

Introduction

Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. An increasing number of studies show that different functional foods and ingredients [9,10] may exert positive effects on particular parameters related to the metabolic syndrome (MetS), a cluster of pathophysiologic conditions increasing cardiometabolic risk [11,12,13]. Such observations may provide the basis for an effective preventive dietary strategy, in which the inclusion of an ample spectrum of active food components or properties may decrease multiple risk factors. The present investigation explores the CMD preventive potential of a diet based on a combination of functional concepts, chosen on the basis of their beneficial effects on single metabolic risk markers

Objectives

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Results

Discussion

Conclusion