Abstract
A diastereoselective Mannich reaction has been developed for the synthesis of chiral β-fluoroamine motifs by the reaction of α-fluoroketones with ketimines, including isatin-derived ketimines and phenylglyoxylate-derived ketimines. This method provides a concise route to a variety of biologically important 3-aminooxindoles and α-amino acids featuring fluorine-containing vicinal tetrasubstituted stereocenters.
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