Abstract
Purpose: to study angioarchitectonics of choroidal melanoma with varied biometric characteristics by comparing the results of indocyanine green angiography (IAG) and OCT angiography (OCTA).Material and methods. Angiography with indocyanine green and OCT angiography was performed in 45 choroidal melanoma patients (45 eyes, 20 men, 25 women, mean age 57.36 ± 15.11 years) to see the features of angioarchitectonics for various tumor elevations: up to 3 mm (small choroidal melanomas) and within the 3.1– 5.0 mm range (medium choroidal melanomas) and assess the informative value of the techniques.Results. We established a high diagnostic value of angiography with indocyanine green and OCT angiography in the diagnosis of vasculature of choroidal melanoma (89% and 71 %, respectively), an acceptable significance in small choroidal melanomas, and a higher informative value of angiography with indocyanine green in medium choroidal melanomas. The vasculature of small choroidal melanomas is characterized by type 1 angioarchitectonics predominance (59 %), while that of medium-sized melanomas corresponds to type 2 angioarchitectonics (81 %). The pattern match in angiography with indocyanine green and OCT angiography took place in 93.8 % of patients. The average depth of vessel identification during OCT angiography was determined to stay within the range of 186 μm for choroidal melanomas of up to 1.9 mm high, 220 μm for melanomas between 2 and 3 mm high, and 255 μm for melanomas higher than 3 mm.Conclusions. The use of contrast and non-contrast angiography in assessing the vasculature of choroidal melanoma is highly informative and useful for the assessment of the type of angioarchitectonics. The use of OCT angiography is more informative for tumors with an elevation of up to 3 mm. In order to increase the accuracy and effectiveness of OCTA, the identification of newly formed vessels should be carried out with regard to the parameters established.
Highlights
Purpose: to study angioarchitectonics of choroidal melanoma with varied biometric characteristics by comparing the results of indocyanine green angiography (IAG) and OCT angiography (OCTA)
Angiography with indocyanine green and OCT angiography was performed in 45 choroidal melanoma patients (45 eyes, 20 men, 25 women, mean age 57.36 ± 15.11 years) to see the features of angioarchitectonics for various tumor elevations: up to 3 mm and within the 3.1– 5.0 mm range and assess the informative value of the techniques
The vasculature of small choroidal melanomas is characterized by type 1 angioarchitectonics predominance (59 %), while that of medium-sized melanomas corresponds to type 2 angioarchitectonics (81 %)
Summary
Инструментальное исследование с применением ИАГ Фишера (в случае малого числа наблюдений). Результаты сравнительного анализа частоты идентиопухоли от 0,6 до 3,0 мм (n = 29), II группу («средние» МХ) — фикации сосудистой сети МХ малых и средних размеров при от 3,1 до 5 мм (n = 16). Проведении ОКТА и ИАГ представлены в таблице 1. ИАГ выполнена 45 пациентам на ретинальном ангиогра- при проведении инвазивной и неинвазивной ангиографии фе-2 (HRA-2 — Heidelberg Retina Angiograph-2 + OCT). Высокая информативность ИАГ в выявлении сосудипользование видеорежима и выполнение снимков начиная стой сети в опухоли, показанная в нашей работе, находится с ранней фазы (до 30 с), затем через каждую минуту до в полном соответствии с результатами других авторов, что окончания средней фазы, затем на 10, 15, 20, 30-й минутах позволяет считать его золотым стандартом в прижизненном исследования. Томографа RTVue XR Avanti (Optovue, Inc., Fremont, CA, США) с применением алгоритма split-spectrum amplitude
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