A detailed observational study of maternal and neonatal variables affecting the thyroid-stimulating hormone levels in neonates

N R Verma,G Naik,R Nanda,T Naik,S Patel,P Padhi

doi:10.1186/s43054-021-00080-0

Abstract

BackgroundThyroid hormones are essential for fetal growth and the central nervous system development. Thyroid-stimulating hormone (TSH) is the key regulatory hormone. Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. These factors should be taken into consideration during newborn screening. This study aimed to observe the impact of maternal and neonatal factors on neonatal TSH status.ResultsNeonatal TSH (nTSH) depicted a positive correlation with parity (p = 0.066) while negative correlation recorded with maternal blood haemoglobin (p = 0.007) among maternal factors.New-born length (p = 0.027) and birth weight (p < 0.001) exhibited a negative correlation with nTSH among neonatal factors.ConclusionsThis study concludes that among all the maternal and neonatal factors, birth weight shows the most influence on nTSH. However, the effect may be compounded by other factors. As these risk elements rarely occur singly, it is often difficult to find the exposure which confer the risk on children. These factors should be considered while interpreting the result of the screening program.

Highlights

Thyroid hormones are essential for fetal growth and the central nervous system development
As these risk elements rarely occur singly, it is often difficult to find the exposure which confer the risk on children
The percentages of babies born with birth weight of less than 1000 g (0.4%), 1000 to 1500 g (3.54%), and 1500 to 2500 g (26.81%). Neonatal TSH (nTSH) exhibited a wide range from 0.46 to 87.80 mIU/L (Table 1)

Summary

Introduction

Thyroid hormones are essential for fetal growth and the central nervous system development. Thyroidstimulating hormone (TSH) is the key regulatory hormone Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. Thyroid hormones are essential for fetal growth and development, for the central nervous system. Thyroid hormone levels are quite dynamic in the perinatal period and are influenced by multiple factors. Several maternal and neonatal factors such as maternal age, maternal anemia, parity of the mother, and fetus growth during the gestational period greatly influence TSH level [2].

Objectives

Methods

Results

Discussion

Conclusion