Abstract
Background: Neoadjuvant chemotherapy (NACT) forms the initial modality of treatment for primarily inoperable locally advanced breast cancer (LABC). A change in hormone receptor status after NACT has important therapeutic and prognostic consequences. The primary objective of this study is to compare Hormone Receptor status before and after neoadjuvant chemotherapy (discordance). The secondary objective is to study correlation between tumour response and hormone receptor expression. Method: This is a descriptive study of 80 LABC patients who received NACT. All patients who underwent core biopsy and ER/PR assessment before and after NACT were included in this study. Data was collected prospectively from each patient in a structured proforma Results and conclusion: The hormone receptor discordance rate & response to NACT was assessed. ER discordance is 16.4%. in 07 patients estrogen receptor(ER) change positive to negative and in 04patients estrogen receptor change negative to positive. PR discordance is 22.4%. In 12 patients Progesterone receptor (PR) change positive to negative and in 03patients progesterone receptor change negative to positive.
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