A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India

Vijayalaxmi V Mogasale,Vidya Pai,Prakash Saldanha,Vittal Mogasale,P D Rekha

doi:10.1038/s41598-021-84293-8

Vijayalaxmi V Mogasale, Vidya Pai + Show 3 more

Open Access

https://doi.org/10.1038/s41598-021-84293-8

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Abstract

The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.

Highlights

The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials
The analysis showed Antimicrobial resistance (AMR) trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable
World Health Organization (WHO), mutations in microorganisms resulting in AMR, which render medicines ineffective and infections persist in the body, increasing the risk of spread to others[1]

Summary

Introduction

The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices. World Health Organization (WHO), mutations in microorganisms resulting in AMR, which render medicines ineffective and infections persist in the body, increasing the risk of spread to others[1]. In 2015, the 68th World Health Assembly endorsed the Global Action Plan on AMR to tackle this global

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