Abstract
1. 1. A description of the antibiotic bacitracin has been presented. 2. 2. Bacitracin is effective against most gram-positive organisms and has been shown to be effective against penicillin-resistant strains. 3. 3. It maintains effective blood levels of about six times the duration of penicillin, but systemically, the problem of its toxicity has not been clarified. Therefore, its topical use only in judicially safe dosage amounts is advocated at this time only. 4. 4. In 150 patients with Vincent's infection, bacitracin was topically applied. Amelioration resulted quickly, thus facilitating limitation and control. 5. 5. Bacitracin may be considered as a useful antibiotic in dentistry for topical application only. Since it has no side effects, it may be most effectively used upon patients who are allergic to penicillin or penicillin-fast. 6. 6. In view of its unclarified status, caution must be used and even topical application dosages should be limited to safe amounts.
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