A Definitive Look at Gianotti-Crosti Syndrome

Abstract

The common dermatosis Gianotti-Crosti syndrome (GCS), which affects children aged 2 to 6 years, was first reported in 1953 by an Italian dermatology resident. He described a unique monomorphous papular rash in children that was associated with fever, mild hepatomegaly, and widespread lymphadenopathy. More than a decade later, the connection to hepatitis B (HBV) infection was proven. In the 1970s, GCS epidemics occurred in Japanese …