A dedicated translation factor controls the synthesis of the global regulator Fis

Abstract

Retraction31 October 2007free access A dedicated translation factor controls the synthesis of the global regulator Fis Róisín M Owens Róisín M Owens School of Biological Sciences, University of Southampton, Southampton, UK Max-Planck-Institut für Molekulare Genetik, Berlin, Germany Search for more papers by this author Gareth Pritchard Gareth Pritchard School of Biological Sciences, University of Southampton, Southampton, UK Search for more papers by this author Paul Skipp Paul Skipp School of Biological Sciences, University of Southampton, Southampton, UK Centre for Proteomic Research, University of Southampton, Southampton, UK Search for more papers by this author Michelle Hodey Michelle Hodey School of Biological Sciences, University of Southampton, Southampton, UK Search for more papers by this author Sean R Connell Sean R Connell Max-Planck-Institut für Molekulare Genetik, Berlin, Germany Search for more papers by this author Knud H Nierhaus Knud H Nierhaus Max-Planck-Institut für Molekulare Genetik, Berlin, Germany Search for more papers by this author C David O'Connor C David O'Connor School of Biological Sciences, University of Southampton, Southampton, UK Centre for Proteomic Research, University of Southampton, Southampton, UK Search for more papers by this author Róisín M Owens Róisín M Owens School of Biological Sciences, University of Southampton, Southampton, UK Max-Planck-Institut für Molekulare Genetik, Berlin, Germany Search for more papers by this author Gareth Pritchard Gareth Pritchard School of Biological Sciences, University of Southampton, Southampton, UK Search for more papers by this author Paul Skipp Paul Skipp School of Biological Sciences, University of Southampton, Southampton, UK Centre for Proteomic Research, University of Southampton, Southampton, UK Search for more papers by this author Michelle Hodey Michelle Hodey School of Biological Sciences, University of Southampton, Southampton, UK Search for more papers by this author Sean R Connell Sean R Connell Max-Planck-Institut für Molekulare Genetik, Berlin, Germany Search for more papers by this author Knud H Nierhaus Knud H Nierhaus Max-Planck-Institut für Molekulare Genetik, Berlin, Germany Search for more papers by this author C David O'Connor C David O'Connor School of Biological Sciences, University of Southampton, Southampton, UK Centre for Proteomic Research, University of Southampton, Southampton, UK Search for more papers by this author Author Information Róisín M Owens1,2, Gareth Pritchard1, Paul Skipp1,3, Michelle Hodey1, Sean R Connell2, Knud H Nierhaus2 and C David O'Connor1,3 1School of Biological Sciences, University of Southampton, Southampton, UK 2Max-Planck-Institut für Molekulare Genetik, Berlin, Germany 3Centre for Proteomic Research, University of Southampton, Southampton, UK The EMBO Journal (2007)26:4607-4607https://doi.org/10.1038/sj.emboj.7601879 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Retraction to: The EMBO Journal (2004) 23, 3375–3385. doi:10.1038/sj.emboj.7600343 In the above report, we presented data indicating that BipA, a protein that shares sequence identity with translational elongation factors, is required for the expression of the transcriptional modulator Fis. As part of our ongoing studies into BipA, we discovered that we were unable to reproduce data presented in Figures 4 and 6C of the paper, which were generated by JGP when he was in CDOC's laboratory. Specifically, we have been unable to reproduce immunoblots indicating that BipA is required for the efficient expression of Fis protein and, using a reconstructed version of the plasmid pJGP1, find that there is no significant difference in the level of Fis translation in the presence or absence of BipA. While we are confident that the experiments concerning the interactions of BipA with 70S ribosomes are valid, we conclude that the results shown in Figures 4 and 6C are unsound and therefore wish to retract the paper. The second author of the paper is no longer at the University of Southampton and has not signed the retraction. The authors apologize for any inconvenience. Next ArticlePrevious Article Read MoreAbout the coverClose modalView large imageVolume 26,Issue 21,October 31, 2007Scientific research often progresses slowly, with small careful steps, similar to the locomotion of this snail (Helix pomatia), which slowly glides forward, guided by its careful flexible eyes. Having studied the genetics of mucopolysaccharidosis and retinitis pigmentosa in the past, the current interests of the photographer, Raf Vervoort, focus on inner ear defects in the mouse. A small portfolio of his photography can be found at www.bvnf.be/portfolio/p_vervoort.htm. Volume 26Issue 2131 October 2007In this issue RelatedDetailsLoading ...