Abstract

Collaborations between academia and industry are vital for modern industrial research and development projects, combining the best of both worlds to develop sustainable chemical processes. Herein we summarize a number of successful cooperations between DSM Nutritional Products and Swiss academic institutions that have been carried out over approximately the past decade. A wide variety of reactions and processes have been investigated with experts located in Switzerland. New synthetic routes, chemical transformations and reactor concepts have been developed to produce industrially relevant compounds. Additionally the scope of known catalytic systems has been probed and new catalysts showing improved selectivity have been designed, synthesized and tested. We describe how the research was supported by DSM, the parallel in-house investigations and also how the projects were continued and further developed.

Highlights

  • The driving force for chemical process research, especially in the fine chemicals’ industry, is the development of sustainable, efficient and low-cost production processes for a wide variety of compounds and products

  • After 270 h on stream, the TOF decreased by 13% compared to the original value; the original catalyst activity was re-established after a thermal treatment, showing the high stability of the catalytic coating of the structured reactors.[10b]. The mini-plant setup was continuously improved and has been transferred to the DSM laboratories (Fig. 2) and additional studies are on-going with further alkyne substrates

  • Words DSM has collaborated with a number of Swiss academics and institutions on a wide variety of topics

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Summary

Introduction

The driving force for chemical process research, especially in the fine chemicals’ industry, is the development of sustainable, efficient and low-cost production processes for a wide variety of compounds and products. Rather than focus on one particular cooperation, what we have aimed to do in this article is to highlight some of the collaborations undertaken in approximately the past ten years in the field of process research These projects were initiated for a variety of reasons such as: investigating a specific transformation that was relevant to a running R&D project at DSM, obtaining more indepth understanding of a particular class of reactions or catalysts where there was limited existing in-house knowledge or testing new technologies and emerging fields for relevance to DSM, and fundamental investigations that would hopefully lead to a stepchange in chemical production. After 270 h on stream, the TOF decreased by 13% compared to the original value; the original catalyst activity was re-established after a thermal treatment, showing the high stability of the catalytic coating of the structured reactors.[10b] The mini-plant setup was continuously improved and has been transferred to the DSM laboratories (Fig. 2) and additional studies are on-going with further alkyne substrates. Up to 30–40% higher reaction rates in the whole range of the investigat-

Asymmetric Homogeneous Hydrogenation Reactions
Acetophenone Synthesis by Solid-Acid Mediated Fries-Rearrangement
Selective Mono-Acetylation of a Vitamin A Intermediate
Vitamin E
Findings
Conclusions and Final Words
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