Abstract
Malignant hyperthermia (MH) is a potentially lethal disorder triggered by certain anesthetics. MH is characterized by hypermetabolism, muscle rigidity, hypercapnia, tachycardia, hypoxaemia, respiratory and metabolic acidosis, and hyperthermia. Mutations in the RYR1(account for about half of MH cases), CACNA1S, or STAC3 genes are associated with MH. We report on the case of a 19-year-old girl who is suffering from MH, without history of MH-susceptible and she died suddenly after cardiac arrest for more than 2 hours. The lack of clinical experience and vigilance resulted to the difficulty of early diagnosis. If MH is highly suspected during general anesthesia of potent volatile anaesthetics with or without succinylcholine, a collaborative treatment approach is mandatory, especially treatmented with dantrolene should begin as soon as possible. Autopsy of patients with MH, similar cases are infrequent in the literature, which is reviewed in this report, explore the pathophysiological changes, we hope that can be helpful for the prevention, diagnosis and treatment of similar cases in time.
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