Abstract
A model is described for the simulation of tritiated thymidine radiotracer studies in mammalian cell populations, which takes into account intracycle age-specific variations in the rate of DNA synthesis and tritiated thymidine incorporation, and their relation to tritium detection characteristics by radioautographic methods. The per cent labeled mitosis curve is considered in detail. The model suggests that the per cent labeled mitosis curve alone does not contain sufficient information for the precise characterization of age structure and growth behavior in heterogeneous cell populations; however, in many instances certain features can be identified which permit the classification of population growth behavior in accordance with broad, but nonetheless useful criteria.
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