A Cytohistological Correlation in Ovarian Tumours

Abstract

The present study was conducted to assess whether imprint cytology can help in rapid diagnosis of ovarian neoplasm and thus facilitate individualized treatment. Aims of our study were to establish the validity and reliability of Imprint cytology in intraoperative diagnosis of ovarian tumour and to compare the significance of cytological diagnosis with histopathological report. Ours is an Institution base prospective study designed on 50 cases of clinically and radiologically diagnosed ovarian tumour at the Dept of pathology IPGME&R, Kolkata which is a tertiary care referral hospital. Imprint smears were made intraoperatively from fresh samples and stained with M.G.G. stain for air dried smears and Papanicolaou stain for alcohol fixed smears. Stained smear was examined under light microscope and cytological findings were noted. Tissue for histopathological study was obtained in the form of post operative material. The previous cytological findings were compared with subsequent histopathology report. Out of total 50 cases, 32(64%) was epithelial tumours and 18(36%) non-epithelial tumour cases. Age group varied from 5 to 62 years. Overall sensitivity in our study to diagnose benign and malignant ovarian tumours by imprint cytology is 94% and the specificity is 74% with positive and negative predictive value of 63% and 96% respectively. Diagnostic accuracy was 78% with high statistical significance (p<0.001). Hence we conclude that imprint cytology is a less expensive, simple, fast and reliable method for diagnosis of various ovarian neoplasms.