Abstract
The effect on mitosis of maleic hydrazide (MH) and its ability to induce chromosomal aberrations and sister chromatid exchanges (SCEs) was studied in root-tips of Allium cepa. Roots were exposed to MH either continuously or for 2 hr and then analyzed for mitotic index. An effect of MH on cell division was evident in all cases, although at the lowest dose, 3 × 10−4 M MH, a recovery of proliferative activity was observed 12 hr after the pulse treatment. This recovery permitted a study of MH-induced chromosome damage and SCEs. MH induced chromatid aberrations and SCEs; its effectiveness depended on the cell cycle stage treated. Possible molecular mechanisms involved in the action of MH are discussed.
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