A cyberphysical synthesis approach for error recovery in digital microfluidic biochips

Abstract

Droplet-based “digital” microfluidics technology has now come of age and software-controlled biochips for healthcare applications are starting to emerge. However, today's digital microfluidic biochips suffer from the drawback that there is no feedback to the control software from the underlying hardware platform. Due to the lack of precision inherent in biochemical experiments, errors are likely during droplet manipulation, but error recovery based on the repetition of experiments leads to wastage of expensive reagents and hard-to-prepare samples. By exploiting recent advances in the integration of optical detectors (sensors) in a digital microfluidics biochip, we present a “physical-aware” system reconfiguration technique that uses sensor data at checkpoints to dynamically reconfigure the biochip. A re-synthesis technique is used to recompute electrode-actuation sequences, thereby deriving new schedules, module placement, and droplet routing pathways, with minimum impact on the time-to-response.